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Developed for busy clinicians, JACC Journals podcasts provide key insights into top cardiovascular science published in the JACC family of Journals. The JACC Podcast features article summaries recorded by Valentin Fuster, MD, PhD, MACC, from each weekly issue of JACC. 

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  2. Disentangling the Impact of Adiposity From Insulin Resistance in HFpEF | JACC Deep Dive

Disentangling the Impact of Adiposity From Insulin Resistance in HFpEF | JACC Deep Dive

May 6, 2025

In a Deep Dive in our May 13 issue, Editor-in-Chief Harlan Krumholz, MD, SM, FACC, discusses a study led by Barry Borlaug that investigates whether excess weight or metabolic dysfunction has a greater impact on heart failure with preserved ejection fraction (HFpEF). The findings showed that obesity—more than insulin resistance—was strongly associated with worse hemodynamic and functional outcomes. Reviewers praised the study's nuanced approach and use of invasive measures, while editorialists emphasized the ongoing importance of addressing both adiposity and metabolic health in HFpEF management.