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JACC Journals podcasts deliver expert insights and key takeaways from the latest cardiovascular science. Hosted by Editor-in-Chief Harlan M. Krumholz, MD, SM, JACC This Week offers engaging summaries and commentary from each weekly issue, complemented by a growing library of deep-dive interviews, global perspectives, and author conversations that highlight the research and innovation shaping cardiovascular medicine worldwide.

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  2. October 21, 2025 - The Adipokine Hypothesis, Adipose-Cardiac Signaling, Sex Differences, Therapeutic Implications, and Diverse Populations | JACC This Week

October 21, 2025 - The Adipokine Hypothesis, Adipose-Cardiac Signaling, Sex Differences, Therapeutic Implications, and Diverse Populations | JACC This Week

Oct 13, 2025

JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, introduces the October 21, 2025 issue of JACC, which is devoted entirely to Dr. Milton Packer’s adipokine hypothesis.  Dr. Krumholz explains the rationale behind dedicating the issue to this bold conceptual framework, which proposes that dysfunctional visceral fat and its secreted adipokines drive HFpEF. We're also thrilled to present readers with 10 accompanying expert commentaries that explore, challenge, and contextualize the hypothesis.