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Developed for busy clinicians, JACC Journals podcasts provide key insights into top cardiovascular science published in the JACC family of Journals. The JACC Podcast features article summaries recorded by Valentin Fuster, MD, PhD, MACC, from each weekly issue of JACC. 

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  2. Sleep and Heart Failure: LV Function Findings from the ADVENT-HF Trial | JACC Baran

Sleep and Heart Failure: LV Function Findings from the ADVENT-HF Trial | JACC Baran

Jun 10, 2025

In this episode, host Mitsuaki Sawano, MD, is joined by Dr. Shoichiro Yatsu, MD, to discuss his sub-analysis of the ADVENT-HF trial, recently published in JACC: Heart Failure. The study investigates the effects of peak-flow-triggered adaptive servo-ventilation (ASVPF) on left ventricular (LV) structure and function in patients with heart failure and sleep-disordered breathing (SDB). Compared to earlier studies using different ASV algorithms, ADVENT-HF highlights the safety and clinical value of ASVPF, showing meaningful improvements in sleep quality, symptoms, and quality of life. Dr. Yatsu also shares insights from managing legacy trial data collected over more than a decade.