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Developed for busy clinicians, JACC Journals podcasts provide key insights into top cardiovascular science published in the JACC family of Journals. The JACC Podcast features article summaries recorded by Valentin Fuster, MD, PhD, MACC, from each weekly issue of JACC. 

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  2. Sodium Zirconium Cyclosilicate for Management of Hyperkalemia During Spironolactone Optimization in Patients with Heart Failure | JACC

Sodium Zirconium Cyclosilicate for Management of Hyperkalemia During Spironolactone Optimization in Patients with Heart Failure | JACC

Mar 10, 2025

In this episode, Dr. Valentin Fuster discusses a study on sodium zirconium cyclosilicate (SZC) for managing hyperkalemia in heart failure patients on mineralocorticoid receptor antagonists (MRAs) like spironolactone. While SZC effectively reduced hyperkalemia and allowed higher spironolactone doses, concerns over worsening heart failure events highlight the complex balance between treatment benefits and risks.